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Kambo is the secretion of the Phyllomedusa bicolor frog, also known as the blue-and-yellow frog, bicoloured tree-frog, giant monkey frog, giant leaf frog, or waxy-monkey tree-frog, with a habitat spanning the Amazon basin and into surrounding areas.


The Kambo secretion contains a mixture of both bio-active, and antimicrobial peptides. The peptides discovered in Kambo (by scientist Vittorio Erspamer, of the University of Rome, 1940’s), trigger a variety of beneficial chemical reactions in the human body.


Kambo has the ability, unlike many other natural substances, to cross the blood-brain barrier, enabling it to reach deep into the body and bring support to otherwise difficult-to-treat areas. As a natural substance that the body recognizes, cells unlock and open to Kambo. This allows the peptides to help clean deposits left in the cells by foreign substances that the cell was not able to process alone, while leaving no stress on the cells. (The role of peptides in the body are similar to that of amino acids, although peptides are MUCH smaller in size and can penetrate more deeply into the body and cells to do their cleaning). Human cells open up to the beneficial properties of Kambo unlike many substances that are filtered and eliminated by the body’s highly intelligent defense system.


Thus far, researchers have discovered nine peptides in Kambo, some of which are bio-active, some are anti-microbial. The U.S. National Library of Medicine published that all the peripheral and most of the central effects of Kambo can be ascribed to the exceptionally high content (up to 7% of its weight) in potently active peptides, easily absorbed through the burned, inflamed areas of the skin. The concentration in Kambo of the single peptides (phyllocaerulein, phyllomedusin, phyllokinin, demorphins and deltorphins) has been determined by bioassay, and peptide contents were correlated with the different symptoms of the Kambo intoxication. These peptides perform hormone-like tasks, while others provide support to vital cellular processes. Some of these peptides have a potent effect on the gastrointestinal muscles, gastric and pancreatic secretions, blood circulation, and on the stimulation of the adrenal cortex and pituitary gland.


Kambo also contains multiple antimicrobial peptides effective against drug resistant strains of bacteria, fungi, protozoa, parasites and viruses, providing opportunities for the development of new and more efficient nanotechnological-based therapies for treating infectious diseases.


Many peptides have since been isolated from the Kambo secretion and have been synthesized. As a testament to their medicinal properties, there are over 70 Kambo patents lodged, mainly in the USA.


The complete list of peptide families represented in Kambo are bradykinins, phyllokinin, tachykinins, phyllomedusin, caerulein, sauvagine, tryptophyllins, dermophins, deltorphins, and bombesins.